| The Chicago Community Trust | Chicago | $26,000 | 8,227 | $7.0B |
| Iff | Chicago | $49,003 | 847 | $109.9M |
| The Rotary Foundation of Rotary | Evanston | $40,000 | 695 | $106.6M |
| National Council of Ymcas of the USA | Chicago | $43,078 | 687 | $150.5M |
| Northwestern University | Evanston | $75,000 | 677 | $559.9M |
| United Way of Metropolitan Chicago Inc | Chicago | $25,271 | 649 | $126.7M |
| Greater Chicago Food Depository | Chicago | $56,708 | 552 | $695.9M |
| Robert R Mccormick Foundation | Chicago | $50,750 | 483 | $314.8M |
| Northwestern Memorial Healthcare Group | Chicago | $25,925 | 386 | $146.7M |
| Muscular Dystrophy Association | Chicago | $36,969 | 283 | $64.2M |
| Action for Healthy Kids | Chicago | $44,926 | 255 | $21.3M |
| Forefront | Chicago | $50,000 | 245 | $33.5M |
| American Medical Association | Chicago | $30,000 | 186 | $30.2M |
| Eastern Illinois Foodbank | Urbana | $47,545 | 130 | $73.8M |
| Illinois Public Health Institute | Chicago | $25,035 | 118 | $7.1M |
| Loyola University of Chicago | Chicago | $28,573 | 109 | $17.8M |
| P33 | Chicago | $25,000 | 108 | $3.3M |
| Rehabilitation Institute of Chicago | Chicago | $37,196 | 102 | $32.1M |
| Coregiving Co | Chicago | $35,062 | 101 | $12.4M |
| United Way of Champaign County | Savoy | $26,577 | 96 | $12.0M |
| People's Action Institute | Chicago | $88,750 | 91 | $24.0M |
| American Epilepsy Society | Chicago | $40,000 | 88 | $7.2M |
| Chicago Cubs Charities | Chicago | $25,000 | 88 | $8.3M |
| Illinois Agricultural Association | Bloomington | $50,686 | 88 | $20.6M |
| National Partnership for New Americans | Chicago | $25,000 | 86 | $5.0M |
| Omega Medical Grants Association | Rosemont | $27,500 | 84 | $7.8M |
| American Dental Association | Chicago | $56,000 | 84 | $32.7M |
| Underwriters Laboratories Inc | Evanston | $30,000 | 84 | $7.7B |
| Jewish United Fund of Metropolitan Chicago | Chicago | $36,800 | 84 | $484.4M |
| Endeavor Health Clinical Operations | Arlington Heights | $86,404 | 84 | $338.2M |
| Heart of Illinois United Way Inc | Peoria | $77,052 | 81 | $30.9M |
| Memorial Health System Group | Springfield | $48,113 | 78 | $63.5M |
| American Property Casualty Insurance Association | Chicago | $25,000 | 76 | $10.3M |
| Global Philanthropy Partnership | Chicago | $47,627 | 73 | $4.3M |
| Depaul University | Chicago | $29,008 | 72 | $11.5M |
| Easter Seals Inc | Chicago | $57,293 | 71 | $108.7M |
| American Academy of Sleep Medicine | Darien | $83,786 | 71 | $12.3M |
| Aisc Holdings Inc | Chicago | $31,000 | 70 | $7.8M |
| Elevate Energy | Chicago | $48,532 | 68 | $13.6M |
| Society of Actuaries Research Institute | Chicago | $25,000 | 67 | $6.1M |
| Illinois Primary Health Care Association | Springfield | $85,115 | 66 | $38.0M |
| The Network Advocating Against Domestic | Chicago | $30,000 | 65 | $3.5M |
| Lawyers Trust Fund of Illinois | Chicago | $90,000 | 64 | $87.3M |
| Illinois Equal Justice Foundation | Chicago | $60,170 | 63 | $49.1M |
| Neurosurgery Research and Education Foundation | Rolling Meadows | $60,000 | 62 | $8.9M |
| Pillars Fund | Chicago | $50,000 | 60 | $8.4M |
| American Association of Nurse | Rosemont | $68,020 | 58 | $19.8M |
| The Chicago Bar Foundation | Chicago | $33,250 | 58 | $33.2M |
| American Bar Endowment | Chicago | $25,000 | 57 | $32.3M |
| Igrb Foundation | Chicago | $47,500 | 52 | $7.5M |
| Bears Care | Lake Forest | $30,000 | 50 | $10.1M |
| Agency for Community Transit | Pontoon Beach | $25,394 | 49 | $3.5M |
| Center for Orthopaedic Trauma | Rosemont | $25,000 | 44 | $2.6M |
| American Hospital Association | Chicago | $25,250 | 43 | $17.4M |
| Cristo Rey Network | Chicago | $78,000 | 42 | $20.3M |
| American College of Chest Physicians | Glenview | $30,000 | 42 | $2.0M |
| Mount Zion Baptist World Missions | Fairfield | $28,850 | 42 | $4.2M |
| Partnership for Cures | Chicago | $40,000 | 41 | $2.6M |
| Saem Research Foundation | Des Plaines | $25,000 | 41 | $3.5M |
| Shure Charitable Trust Created Uw of Sidney N Shure | Chicago | $25,000 | 39 | $15.5M |
| Impact Grants Chicago | Chicago | $49,714 | 39 | $2.5M |
| Heartland Alliance for Human Needs and Rights | Chicago | $52,720 | 38 | $23.2M |
| Acclivus Inc | Chicago | $90,731 | 37 | $6.8M |
| Masonic Family Health Services | Chicago | $25,000 | 36 | $7.3M |
| World Business Chicago | Chicago | $25,000 | 36 | $2.2M |
| Orthopaedic Research and Education | Rosemont | $25,000 | 36 | $6.1M |
| The Barack Obama Foundation | Chicago | $50,000 | 36 | $28.3M |
| Society of Critical Care Medicine | Mount Prospect | $30,000 | 35 | $2.1M |
| Illinois Science and Technology | Chicago | $74,908 | 35 | $2.5M |
| American Bar Association Fund for Justice and Education | Chicago | $75,818 | 34 | $27.6M |
| Osf Healthcare System | Peoria | $50,000 | 33 | $28.3M |
| Chicago Food Policy Action Council | Chicago | $46,250 | 32 | $5.0M |
| Families of Spinal Muscular Atrophy | Schaumburg | $41,932 | 32 | $8.0M |
| American Society for Surgery of the Hand | Chicago | $35,000 | 31 | $7.8M |
| Illinois Association of Court Appointed | Chicago | $99,378 | 31 | $20.3M |
| Public Health Institute of Metropolitan | Chicago | $45,299 | 31 | $6.1M |
| Blue Cross Blue Shield Association | Chicago | $43,500 | 30 | $3.2M |
| Healthcare Foundation of | Highland Park | $40,000 | 30 | $7.5M |
| Covenant Ministries of Benevolence | Chicago | $44,250 | 30 | $3.0M |
| Agudath Israel of Illinois | Chicago | $75,000 | 30 | $4.7M |
| Pert Foundation | Chicago | $25,000 | 30 | $327.6M |
| American Society of Anesthesiologists | Schaumburg | $25,000 | 29 | $11.1M |
| Pci Foundation | Chicago | $60,000 | 29 | $1.9M |
| Illinois Association of Community Action | Springfield | $93,690 | 29 | $17.1M |
| Think Big America | Chicago | $62,500 | 29 | $7.4M |
| Foundation for Women's Cancer | Chicago | $50,000 | 28 | $2.5M |
| Wisconsin Chapter of the American | Chicago | $25,000 | 27 | $816K |
| Institute of Food Technologists | Chicago | $25,000 | 27 | $1.5M |
| Leonard and Diane Sherman Family | Chicago | $26,800 | 27 | $5.6M |
| The Society for the Preservation | Champaign | $29,067 | 27 | $2.9M |
| Illinois Stewardship Alliance | Springfield | $26,900 | 27 | $1.7M |
| National Safety Council | Itasca | $80,384 | 26 | $3.3M |
| Sigma Alpha Epsilon Foundation | Evanston | $65,097 | 26 | $5.3M |
| The Carle Foundation Hospital | Urbana | $50,000 | 26 | $4.8M |
| Rate Foundation Nfp | Chicago | $56,041 | 26 | $7.0M |
| North Shore Exchange Nfp | Glencoe | $30,000 | 26 | $2.2M |
| Alianza Americas | Chicago | $43,325 | 25 | $4.9M |
| Council of Medical Specialty Societies | Chicago | $50,000 | 25 | $12.9M |
| Carole Robertson Center for Learning | Chicago | $63,868 | 24 | $24.1M |
| Prevent Child Abuse America | Chicago | $40,000 | 23 | $2.1M |
| Pediatric Orthopaedic Society of | Oakbrook Terrace | $30,000 | 23 | $1.0M |
| Faith and Learning International Nfp | Wheaton | $25,950 | 22 | $1.2M |
| Bls Family Foundation | Chicago | $27,500 | 22 | $2.4M |
| Midwest Region Organizing Committee | Springfield | $58,301 | 22 | $4.9M |
| The American Laryngological Rhinological | Oak Brook | $40,000 | 22 | $1.9M |
| Alliance to End Homelessness in | Hillside | $61,011 | 21 | $5.2M |
| Kehillah Jewish Education Fund | Skokie | $31,218 | 21 | $4.8M |
| HIRE360 | Chicago | $65,692 | 21 | $3.7M |
| Society for Vascular Surgery Foundation | Rosemont | $52,500 | 20 | $2.3M |
| Precastprestressed Concrete Institute | Chicago | $50,000 | 20 | $1.7M |
| Peoria Hospitals Mobile Medical Services | Peoria | $25,000 | 20 | $2.9M |
| Together Chicago Inc | Chicago | $25,000 | 20 | $858K |