| The Blackbaud Giving Fund | Charleston Sc | $11,041 | 32,011 | $1.4B |
| Central Carolina Community | Columbia | $15,869 | 931 | $93.9M |
| Coastal Community Foundation of South | N Charleston | $15,925 | 691 | $67.2M |
| South Carolina Christian Foundation | Spartanburg | $15,000 | 483 | $38.3M |
| Spartanburg County Foundation | Spartanburg | $16,750 | 436 | $101.1M |
| Community Foundation of the Lowcountry | Hilton Head Island | $15,000 | 278 | $31.6M |
| Carolinas Credit Union Foundation | Columbia | $10,000 | 247 | $5.7M |
| Lowcountry Food Bank Inc | Charleston | $102,696 | 230 | $249.3M |
| Prisma Health | Greenville | $15,000 | 173 | $148.6M |
| Uncommon Charitable Impact Inc | Charleston | $13,137 | 169 | $17.2M |
| United States Endowment for Forestry | Greenville | $78,378 | 162 | $35.1M |
| Waccamaw Community Foundation | Murrells Inlet | $11,925 | 150 | $11.9M |
| United Way of the Piedmont Inc | Spartanburg | $21,625 | 142 | $10.2M |
| United Way of Greenville County Inc | Greenville | $40,000 | 121 | $16.1M |
| The Movement Foundation Inc | Fort Mill | $12,475 | 118 | $50.8M |
| Frances P Bunnelle Foundation | Pawleys Island | $15,750 | 113 | $9.9M |
| Dabo's All in Team Foundation | Clemson | $8,000 | 108 | $1.9M |
| Palmettopride the Governor's | Columbia | $10,000 | 108 | $3.2M |
| Advanced Technology International | Summerville | $10,000 | 104 | $14.9M |
| Heritage Classic Foundation | Hilton Head Island | $21,387 | 98 | $10.6M |
| Pledge the Pink Foundation | Bluffton | $10,000 | 97 | $3.0M |
| Trident United Way | North Charleston | $14,300 | 97 | $5.8M |
| South Carolina Humanities Council | Columbia | $11,000 | 92 | $1.5M |
| Together Women Rise | Greenville | $49,945 | 85 | $4.8M |
| Children's Trust of South Carolina | Columbia | $119,837 | 81 | $54.6M |
| Upward Unlimited | Spartanburg | $15,000 | 79 | $5.0M |
| Eastern Carolina Community Foundation | Florence | $12,940 | 76 | $2.6M |
| South Carolina Association for | Charleston | $10,000 | 72 | $4.2M |
| Fact Forward | Columbia | $25,000 | 68 | $5.5M |
| Palmetto Promise Institute | Columbia | $9,000 | 65 | $1.7M |
| United Way of the Midlands | Columbia | $50,000 | 61 | $23.2M |
| United Way Association of South | Columbia | $157,443 | 60 | $27.2M |
| Sisk Foundation | Greenville | $10,000 | 58 | $1.6M |
| Hollingsworth Funds Inc | Greenville | $75,000 | 58 | $44.3M |
| The Church Mouse Thrift Shop Inc | Hilton Head Island | $13,000 | 57 | $2.6M |
| Spinks Family Foundation | Greenville | $24,000 | 56 | $5.0M |
| Southeast Coastal Ocean Observing | Charleston | $75,841 | 50 | $18.4M |
| Daniel Island Community Fund Inc | Charleston | $10,175 | 49 | $2.6M |
| South Carolina First Steps to | Columbia | $307,613 | 48 | $221.7M |
| South Carolina Physicians Care Charity | Chapin | $30,000 | 47 | $2.5M |
| Municipal Association of South Carolina | Columbia | $25,000 | 47 | $1.4M |
| St Francis Hospital Inc | Greenville | $12,500 | 44 | $1.7M |
| Darlington Community Foundation | Darlington | $8,000 | 44 | $675K |
| Spartanburg Regional Healthcare System Foundation | Spartanburg | $10,167 | 42 | $7.2M |
| National Council of Examiners for Engineering and Surveying | Greenville | $10,000 | 41 | $12.0M |
| York Electric Trust Inc | York | $10,000 | 41 | $1.5M |
| The South Carolina Bar Foundation | Columbia | $37,000 | 40 | $12.3M |
| United Way of the Lowcountry | Beaufort | $26,250 | 39 | $4.1M |
| Palmetto Electric Trust | Ridgeland | $13,322 | 39 | $1.3M |
| Wexford Foundation | Hilton Head Island | $12,000 | 38 | $2.4M |
| South Carolina Student Loan Corp | Columbia | $40,000 | 38 | $2.5M |
| Medical Society of South Carolina | Charleston | $20,000 | 34 | $1.4M |
| Jewish Endowment Foundation of South | N Charleston | $14,794 | 33 | $3.4M |
| Medical Technology Enterprise Consortium | Summerville | $37,500 | 32 | $3.3M |
| Beyond Our Gates Foundation of Kiawah & | Johns Island | $20,000 | 31 | $1.3M |
| United Way of Anderson County | Anderson | $17,000 | 30 | $1.9M |
| United Way of Horry County Inc | Myrtle Beach | $17,500 | 30 | $1.2M |
| Roper St Francis Healthcare | Ladson | $10,000 | 29 | $506K |
| Harvest Christian Ministries Inc | Abbeville | $19,200 | 29 | $1.4M |
| The Premier Foundation | Greer | $100,000 | 28 | $8.5M |
| Michelin Charity Golf Tournament | Greenville | $67,300 | 27 | $3.7M |
| Habitat for Humanity South Carolina | Columbia | $20,000 | 27 | $1.6M |
| Marion County Healthcare Foundation | Mullins | $42,575 | 25 | $4.6M |
| South Carolina Medical Association | Columbia | $20,000 | 24 | $1.1M |
| Anmed Health | Anderson | $11,000 | 24 | $3.1M |
| United Way of York County Sc | Rock Hill | $21,380 | 24 | $1.4M |
| United Way of Aiken County Inc | Aiken | $42,360 | 24 | $7.5M |
| First Presbyterian Church Foundation | Greenville | $10,000 | 24 | $709K |
| The Charles W & Elizabeth H Coker | Hartsville | $25,000 | 23 | $2.4M |
| The Reserve at Lake Keowee Charitable | Sunset | $20,000 | 23 | $2.2M |
| South Carolina Independent Colleges and | Columbia | $32,262 | 23 | $3.5M |
| United Way of Florence County | Florence | $4,192 | 22 | $2.8M |
| Charity Ball Board of Greenville | Greenville | $20,000 | 22 | $929K |
| South Carolina Childrens Fund | Columbia | $30,000 | 22 | $1.0M |
| South Carolina Association of Pregnancy | Aiken | $139,333 | 21 | $7.2M |
| Chester Healthcare Foundation | Chester | $10,000 | 21 | $763K |
| The Berkeley Hall Charitable | Bluffton | $15,000 | 21 | $1.3M |
| Balmer Foundation | Spartanburg | $25,000 | 21 | $13.2M |
| Tap Cancer Out Inc | Indian Land | $100,000 | 21 | $5.5M |